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JAMA: "Telomerase Makes Old Cells Young Again"  http://jama.ama-assn.org/cgi/content/abstract/279/21/1732

CNN: "Scientists Discover Cellular Fountain of Youth" http://www.cnn.com/HEALTH/9801/13/life.extention/

SCIENCE: "Extension of Life-Span by Introduction of Telomerase" http://www.sciencemag.org/cgi/content/abstract/279/5349/349?ck=nck

CLONTECH: "Telomerase Immortalizes Cells Life-Span from 80 to 300" http://clontech.com/images/pt/dis_manuals/PT3358-1.pdf

SENESCENCE: "Anti-Aging Medicine" http://www.senescence.info/antiaging.html

BARNES AND NOBLE: "The Immortality Enzyme: Bionedical Breakthoughs You Can Use Against Aging..."  http://search.barnesandnoble.com/The-Immortality-Enzyme/Phillip-D-Minton/e/9781884367052

WELLNESS RESEARCH: "Anti-Aging Part-2" http://www.wellnessresearch.org/ha32.php

VIEWZONE: "Human Immortality: A Scientific Reality?"  http://www.viewzone.com/aging.html

ANTI-AGING TODAY: "The Telomerase Theory of Aging" http://www.anti-aging-today.org/aging/theory/telomerase.htm

 

 

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119 Mehle, C., Piatyszek, M.A., Ljungberg, B., Shay, J.W. and Roos, G. (1996) Telomerase activity in human renal cell carcinoma. Oncogene, 13, 161–166.

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126 Yashima, K., Maitra, A., Timmons, C.F., Rogers, B.B., Pinar, H., Shay, J.W. and Gazdar, A.F. (1998) Expression of the RNA component of telomerase in Wilm’s tumor and its precursor lesion recapitulates renal embryogenesis. Hum. Pathol., 28, 536–542.

127 Yashima, K., Ashfaq, R., Nowak, J., Von Gruenigen, V., Milchgrub, S., Rathi, A., Albores-Saavedra, J., Shay, J.W. and Gazdar, A.F. (1998) Telomerase activity and expression of its RNA component in cervical lesions. Cancer, 82, 1319–1327.

128 Morales, C.P., Lee, E.L. and Shay, J.W. (1998) In situ hybridization for the detection of telomerase RNA in the progression from Barrett’s esophagus to esophageal adenocarcinoma. Cancer, 83, 652–659.

129 Ramirez, R.D., D’Atri, S., Pagani, E., Faraggiana, T., Lacal, P.M., Taylor, R.S. and Shay, J.W. (1999) Progressive increase in telomerase activity from benign melanocytic conditions to malignant melanoma. Neoplasia, 1, 42–49.

130 Tatsumoto, N., Hiyama, E., Murakami, Y., Imamura, Y., Shay, J.W., Matsuura, Y. and Yokoyama, T. (2000) High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer. Clin. Cancer Res., 6, 2696–2701.

131 Hiyama, E., Saeki, T., Hiyama, K., Takashima, S., Shay, J.W., Matsuura, Y. and Yokayama, T. (2000) Telomerase activity as a marker of breast carcinoma in fine-needle aspirated samples. Cancer, 90, 235–238.

132 Hiyama, E., Hiyama, K., Yokoyama, T. and Shay, J.W. (2001) Immunohistochemical detection of telomerase (hTERT) protein in human cancer tissues and a subset of cells in normal tissues. Neoplasia, 3, 17–26.

133 Shay, J.W. and Gazdar, A.F. (1997) Telomerase in the early detection of cancer. J. Clin. Pathol., 50, 106–109.

134 Herbert, B.-S., Pitts, A.E., Baker, S.I., Hamilton, S.E., Wright, W.E., Shay, J.W. and Corey, D.R. (1999) Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl Acad. Sci. USA, 96, 14276–14281.

135 Herbert, B.-S., Wright, A.C., Passons, C.M., Ali, I., Wright, W.E., Kopelovich, L. and Shay, J.W. (2001) Inhibition of the spontaneous immortalization of breast epithelial cells from individuals predisposed to breast cancer: Effects of chemopreventive and anti-telomerase agents. J. Natl Cancer Inst., 93, 39–45.

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137 Shammas, M.A., Simmons, C.G., Corey, D.R. and Schmooker Reis, R.J. (1999) Telomerase inhibition by peptide nucleic acids reverses ‘immortality’ of transformed human cells. Oncogene, 18, 6191–6200.

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148 Rosenberg, S.A., Yang, J.C., Schwartzentruber, D.J., Hwu, P., Marincola, F.M., Topalian, S.L., Restifo, N.P., Dudley, M.E., Schwarz, S.L., Spiess, P.J. et al. (1998) Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nature Med., 4, 321–327.

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150 Hahn, W.C., Stewart, S.A., Brooks, M.W., York, S.G., Eaton, E., Kurachi, A., Beijersbergen, R.L., Knoll, J.H., Meyerson, M. and Weinberg, R.A. (1999) Inhibition of telomerase limits the growth of human cancer cells. Nature Med., 5, 1164–1170.

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